Drug interactions
Dabrafenib + Salmeterol
Severity: Minor
Dabrafenib and Salmeterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may reduce salmeterol exposure. The clinical effect on inhaled salmeterol is likely small but could reduce symptom control.
What this interaction means in plain words
Dabrafenib and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Salmeterol belongs to Respiratory.
Why it happens
CYP3A4 induction by dabrafenib increases salmeterol clearance.
What to do
Monitor respiratory symptom control during dabrafenib therapy. Adjust the respiratory regimen if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Salmeterol?
MediHelp rates the interaction as minor. Dabrafenib and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and may reduce salmeterol exposure. The clinical effect on inhaled salmeterol is likely small but could reduce symptom control.
How serious is the interaction between Dabrafenib and Salmeterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptom control during dabrafenib therapy. Adjust the respiratory regimen if control worsens.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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