Drug interactions
Dabrafenib + Sorafenib
Severity: Moderate
Dabrafenib and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib inhibits CYP2C8 in vitro, and dabrafenib is partly cleared through CYP2C8, so dabrafenib exposure could rise. The clinical significance is uncertain, and both agents share overlapping toxicities such as skin reactions.
What this interaction means in plain words
Dabrafenib and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Possible inhibition of CYP2C8-mediated dabrafenib metabolism by sorafenib, with overlapping dermatologic toxicity.
What to do
Monitor for dabrafenib adverse effects such as fever, rash and hand-foot skin reaction. Reduce the dose of dabrafenib if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Sorafenib?
MediHelp rates the interaction as moderate. Dabrafenib and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib inhibits CYP2C8 in vitro, and dabrafenib is partly cleared through CYP2C8, so dabrafenib exposure could rise. The clinical significance is uncertain, and both agents share overlapping toxicities such as skin reactions.
How serious is the interaction between Dabrafenib and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dabrafenib adverse effects such as fever, rash and hand-foot skin reaction. Reduce the dose of dabrafenib if toxicity develops.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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