Drug interactions
Dabrafenib + Tadalafil
Severity: Moderate
Dabrafenib and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower tadalafil plasma concentrations. Reduced efficacy of tadalafil may result, which matters most when it is used for pulmonary arterial hypertension.
What this interaction means in plain words
Dabrafenib and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Tadalafil belongs to Genitourinary.
Why it happens
Dabrafenib induces CYP3A4, accelerating tadalafil clearance.
What to do
Monitor clinical response to tadalafil and adjust the dose if efficacy is lost. Consider an alternative agent if control cannot be maintained.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Tadalafil?
MediHelp rates the interaction as moderate. Dabrafenib and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower tadalafil plasma concentrations. Reduced efficacy of tadalafil may result, which matters most when it is used for pulmonary arterial hypertension.
How serious is the interaction between Dabrafenib and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to tadalafil and adjust the dose if efficacy is lost. Consider an alternative agent if control cannot be maintained.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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