Drug interactions
Dabrafenib + Tamoxifen
Severity: Moderate
Dabrafenib and Tamoxifen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and may lower tamoxifen concentrations. Reduced exposure may compromise tamoxifen efficacy.
What this interaction means in plain words
Dabrafenib and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Tamoxifen belongs to Endocrine.
Why it happens
Induction of CYP3A4 (and other enzymes) by dabrafenib increases tamoxifen clearance.
What to do
Monitor for loss of tamoxifen effect and consider an alternative therapy if the combination is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Tamoxifen?
MediHelp rates the interaction as moderate. Dabrafenib and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib is a CYP3A4 inducer and may lower tamoxifen concentrations. Reduced exposure may compromise tamoxifen efficacy.
How serious is the interaction between Dabrafenib and Tamoxifen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of tamoxifen effect and consider an alternative therapy if the combination is prolonged.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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