Drug interactions
Dabrafenib + Tolvaptan
Severity: Moderate
Dabrafenib and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and can lower tolvaptan exposure. Reduced tolvaptan effect could cause inadequate sodium correction or loss of therapeutic response.
What this interaction means in plain words
Dabrafenib and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Tolvaptan belongs to Endocrine.
Why it happens
Dabrafenib induces CYP3A4, increasing tolvaptan metabolism.
What to do
Monitor serum sodium and clinical response and increase the tolvaptan dose if needed. Avoid it if a stable response cannot be achieved.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Tolvaptan?
MediHelp rates the interaction as moderate. Dabrafenib and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and can lower tolvaptan exposure. Reduced tolvaptan effect could cause inadequate sodium correction or loss of therapeutic response.
How serious is the interaction between Dabrafenib and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and clinical response and increase the tolvaptan dose if needed. Avoid it if a stable response cannot be achieved.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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