Drug interactions
Dabrafenib + Vincristine
Severity: Moderate
Dabrafenib and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower vincristine concentrations, potentially reducing its antitumor efficacy. The clinical significance has not been well characterized.
What this interaction means in plain words
Dabrafenib and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Vincristine belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4, increasing vincristine metabolism.
What to do
Monitor for reduced therapeutic response to vincristine. Consider alternative therapy if loss of efficacy is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Vincristine?
MediHelp rates the interaction as moderate. Dabrafenib and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower vincristine concentrations, potentially reducing its antitumor efficacy. The clinical significance has not been well characterized.
How serious is the interaction between Dabrafenib and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced therapeutic response to vincristine. Consider alternative therapy if loss of efficacy is suspected.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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