Drug interactions
Dacarbazine + Hydroxyurea
Severity: Moderate
Dacarbazine and Hydroxyurea: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress the bone marrow, so combining them may cause more severe leukopenia, thrombocytopenia and anemia. The risk of infection and bleeding rises accordingly.
What this interaction means in plain words
Dacarbazine and Hydroxyurea can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacarbazine belongs to Oncology; Hydroxyurea belongs to Miscellaneous.
Why it happens
Additive myelosuppression from two cytotoxic agents.
What to do
Monitor complete blood counts regularly. Reduce doses or interrupt therapy if counts fall markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dacarbazine
Other interactions of Hydroxyurea
Frequently asked questions
Can I take Dacarbazine with Hydroxyurea?
MediHelp rates the interaction as moderate. Dacarbazine and Hydroxyurea can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress the bone marrow, so combining them may cause more severe leukopenia, thrombocytopenia and anemia. The risk of infection and bleeding rises accordingly.
How serious is the interaction between Dacarbazine and Hydroxyurea?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly. Reduce doses or interrupt therapy if counts fall markedly.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Dacarbazine page.
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