Drug interactions
Dacarbazine + Ifosfamide
Severity: Moderate
Dacarbazine and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both cytotoxic drugs suppress bone marrow, so used together they can cause more severe leukopenia and thrombocytopenia. This is often seen in combination sarcoma regimens.
What this interaction means in plain words
Dacarbazine and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacarbazine belongs to Oncology; Ifosfamide belongs to Oncology.
Why it happens
Additive myelosuppression.
What to do
Monitor complete blood counts regularly and modify doses or delay cycles based on counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Dacarbazine
Frequently asked questions
Can I take Dacarbazine with Ifosfamide?
MediHelp rates the interaction as moderate. Dacarbazine and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both cytotoxic drugs suppress bone marrow, so used together they can cause more severe leukopenia and thrombocytopenia. This is often seen in combination sarcoma regimens.
How serious is the interaction between Dacarbazine and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and modify doses or delay cycles based on counts.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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