Drug interactions
Dactinomycin + Palifermin
Severity: Major
Dactinomycin and Palifermin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial cell growth, and when given close to cytotoxic chemotherapy it may make rapidly dividing mucosal cells more vulnerable. Giving it within 24 hours of chemotherapy has been associated with more severe and longer-lasting oral mucositis.
What this interaction means in plain words
Dactinomycin and Palifermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dactinomycin belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin-induced proliferation of epithelial cells may increase their sensitivity to cytotoxic damage when exposure overlaps.
What to do
Do not give palifermin within 24 hours before, during, or within 24 hours after dactinomycin. Follow the labeled timing around chemotherapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dactinomycin
Other interactions of Palifermin
Frequently asked questions
Can I take Dactinomycin with Palifermin?
MediHelp rates the interaction as major. Dactinomycin and Palifermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palifermin stimulates epithelial cell growth, and when given close to cytotoxic chemotherapy it may make rapidly dividing mucosal cells more vulnerable. Giving it within 24 hours of chemotherapy has been associated with more severe and longer-lasting oral mucositis.
How serious is the interaction between Dactinomycin and Palifermin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during, or within 24 hours after dactinomycin. Follow the labeled timing around chemotherapy.
What other medicines interact with Dactinomycin?
MediHelp also lists interactions of Dactinomycin with, for example, Adenovirus types 4 and 7 live, Belatacept, Dengue vaccine. The full list is on the Dactinomycin page.
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