Drug interactions
Dacarbazine + Trastuzumab
Severity: Moderate
Dacarbazine and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab given with myelosuppressive chemotherapy has been associated with more neutropenia and febrile neutropenia. Dacarbazine is itself myelosuppressive, so the infection risk may be higher.
What this interaction means in plain words
Dacarbazine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacarbazine belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive neutropenia when trastuzumab is combined with cytotoxic chemotherapy; the exact mechanism is not fully established.
What to do
Monitor neutrophil counts and watch for fever or infection. Treat neutropenia per standard protocols and adjust chemotherapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dacarbazine
Other interactions of Trastuzumab
Frequently asked questions
Can I take Dacarbazine with Trastuzumab?
MediHelp rates the interaction as moderate. Dacarbazine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab given with myelosuppressive chemotherapy has been associated with more neutropenia and febrile neutropenia. Dacarbazine is itself myelosuppressive, so the infection risk may be higher.
How serious is the interaction between Dacarbazine and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and watch for fever or infection. Treat neutropenia per standard protocols and adjust chemotherapy as needed.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Dacarbazine page.
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