Drug interactions
Danazol + Deflazacort
Severity: Moderate
Danazol and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol inhibits CYP3A4 and can increase exposure to deflazacort's active metabolite. This raises the risk of corticosteroid adverse effects.
What this interaction means in plain words
Danazol and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4, decreasing clearance of deflazacort's active metabolite.
What to do
Reduce the deflazacort dose to about one third of the usual dose when given with CYP3A4 inhibitors, as per labeling. Monitor for steroid adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Danazol with Deflazacort?
MediHelp rates the interaction as moderate. Danazol and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol inhibits CYP3A4 and can increase exposure to deflazacort's active metabolite. This raises the risk of corticosteroid adverse effects.
How serious is the interaction between Danazol and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the deflazacort dose to about one third of the usual dose when given with CYP3A4 inhibitors, as per labeling. Monitor for steroid adverse effects.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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