Drug interactions
Danazol + Desogestrel-ethinyl estradiol
Severity: Moderate
Danazol and Desogestrel-ethinyl estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol may increase ethinyl estradiol levels through CYP3A4 inhibition. Danazol is also an androgenic agent that is contraindicated in pregnancy, and it opposes estrogen effects, so combined use is generally counterproductive.
What this interaction means in plain words
Danazol and Desogestrel-ethinyl estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4, reducing metabolism of ethinyl estradiol.
What to do
Monitor for estrogenic adverse effects including thromboembolic risk. Danazol requires effective non-hormonal contraception, so review the contraceptive plan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Frequently asked questions
Can I take Danazol with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as moderate. Danazol and Desogestrel-ethinyl estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol may increase ethinyl estradiol levels through CYP3A4 inhibition. Danazol is also an androgenic agent that is contraindicated in pregnancy, and it opposes estrogen effects, so combined use is generally counterproductive.
How serious is the interaction between Danazol and Desogestrel-ethinyl estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects including thromboembolic risk. Danazol requires effective non-hormonal contraception, so review the contraceptive plan.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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