Drug interactions
Danazol + Diazepam
Severity: Moderate
Danazol and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol inhibits CYP3A4 and can raise diazepam levels, enhancing and prolonging sedation and psychomotor impairment.
What this interaction means in plain words
Danazol and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of diazepam.
What to do
Monitor for excessive sedation and lower the diazepam dose as needed. Advise patients about impaired alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Frequently asked questions
Can I take Danazol with Diazepam?
MediHelp rates the interaction as moderate. Danazol and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol inhibits CYP3A4 and can raise diazepam levels, enhancing and prolonging sedation and psychomotor impairment.
How serious is the interaction between Danazol and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and lower the diazepam dose as needed. Advise patients about impaired alertness.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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