Drug interactions
Danazol + Docetaxel
Severity: Moderate
Danazol and Docetaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor and may increase docetaxel exposure. This could intensify myelosuppression and other adverse effects. Clinical data are limited.
What this interaction means in plain words
Danazol and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4, decreasing docetaxel metabolism.
What to do
Monitor blood counts and docetaxel toxicity. Reduce the docetaxel dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Frequently asked questions
Can I take Danazol with Docetaxel?
MediHelp rates the interaction as moderate. Danazol and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak to moderate CYP3A4 inhibitor and may increase docetaxel exposure. This could intensify myelosuppression and other adverse effects. Clinical data are limited.
How serious is the interaction between Danazol and Docetaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and docetaxel toxicity. Reduce the docetaxel dose if adverse effects occur.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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