Drug interactions
Danazol + Erlotinib
Severity: Moderate
Danazol and Erlotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol inhibits CYP3A4 and may raise erlotinib levels. This could increase rash, diarrhea and other adverse effects.
What this interaction means in plain words
Danazol and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4, reducing erlotinib metabolism.
What to do
Monitor for erlotinib adverse effects and reduce the dose if they emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Danazol with Erlotinib?
MediHelp rates the interaction as moderate. Danazol and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol inhibits CYP3A4 and may raise erlotinib levels. This could increase rash, diarrhea and other adverse effects.
How serious is the interaction between Danazol and Erlotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erlotinib adverse effects and reduce the dose if they emerge.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
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