Drug interactions
Danazol + Fludrocortisone
Severity: Minor
Danazol and Fludrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both fludrocortisone and danazol can cause sodium and fluid retention. Together they may increase edema and raise blood pressure, which matters in patients with heart failure, renal disease or hypertension.
What this interaction means in plain words
Danazol and Fludrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive sodium and water retention through mineralocorticoid effect and androgen-related fluid retention.
What to do
Monitor weight, edema and blood pressure, and reduce doses or add diuretic therapy if fluid retention develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Danazol with Fludrocortisone?
MediHelp rates the interaction as minor. Danazol and Fludrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both fludrocortisone and danazol can cause sodium and fluid retention. Together they may increase edema and raise blood pressure, which matters in patients with heart failure, renal disease or hypertension.
How serious is the interaction between Danazol and Fludrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema and blood pressure, and reduce doses or add diuretic therapy if fluid retention develops.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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