Drug interactions
Danazol + Glyburide-metformin
Severity: Moderate
Danazol and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol, an androgenic steroid, can cause insulin resistance and impair glucose tolerance, which tends to raise blood glucose and reduce the effect of glyburide and metformin. Glycemic control may deteriorate and dose changes may be needed.
What this interaction means in plain words
Danazol and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol-induced insulin resistance and altered glucose tolerance antagonize the antidiabetic drugs.
What to do
Monitor blood glucose when danazol is started, changed or stopped. Adjust antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Danazol with Glyburide-metformin?
MediHelp rates the interaction as moderate. Danazol and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol, an androgenic steroid, can cause insulin resistance and impair glucose tolerance, which tends to raise blood glucose and reduce the effect of glyburide and metformin. Glycemic control may deteriorate and dose changes may be needed.
How serious is the interaction between Danazol and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when danazol is started, changed or stopped. Adjust antidiabetic doses as needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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