Drug interactions
Danazol + Insulin degludec
Severity: Moderate
Danazol and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol can induce insulin resistance and impair glucose tolerance. Patients on insulin degludec may therefore lose glycemic control and need larger insulin doses.
What this interaction means in plain words
Danazol and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through androgen-mediated insulin resistance.
What to do
Check blood glucose more frequently when danazol is started or stopped. Titrate insulin degludec to response, and reduce the dose again if danazol is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Frequently asked questions
Can I take Danazol with Insulin degludec?
MediHelp rates the interaction as moderate. Danazol and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol can induce insulin resistance and impair glucose tolerance. Patients on insulin degludec may therefore lose glycemic control and need larger insulin doses.
How serious is the interaction between Danazol and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more frequently when danazol is started or stopped. Titrate insulin degludec to response, and reduce the dose again if danazol is withdrawn.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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