Drug interactions
Danazol + Metformin-pioglitazone
Severity: Moderate
Danazol and Metformin-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol can cause insulin resistance and impaired glucose tolerance, so it may reduce the effectiveness of metformin and pioglitazone. Glycemic control may worsen during treatment.
What this interaction means in plain words
Danazol and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgenic effects of danazol reduce insulin sensitivity, opposing antidiabetic drugs.
What to do
Monitor blood glucose and HbA1c during danazol therapy and adjust antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Danazol and Metformin-pioglitazone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Metformin-pioglitazone
Frequently asked questions
Can I take Danazol with Metformin-pioglitazone?
MediHelp rates the interaction as moderate. Danazol and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol can cause insulin resistance and impaired glucose tolerance, so it may reduce the effectiveness of metformin and pioglitazone. Glycemic control may worsen during treatment.
How serious is the interaction between Danazol and Metformin-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c during danazol therapy and adjust antidiabetic doses as needed.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
