Drug interactions
Danazol + Metformin-repaglinide
Severity: Minor
Danazol and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol can impair glucose tolerance and insulin sensitivity, which may weaken the control achieved by antidiabetic drugs. It also inhibits CYP3A4, which may raise repaglinide levels, so the net effect on glucose is unpredictable.
What this interaction means in plain words
Danazol and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Danazol induces insulin resistance and inhibits CYP3A4 metabolism of repaglinide.
What to do
Monitor blood glucose when danazol is started or stopped. Adjust antidiabetic doses as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Danazol with Metformin-repaglinide?
MediHelp rates the interaction as minor. Danazol and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol can impair glucose tolerance and insulin sensitivity, which may weaken the control achieved by antidiabetic drugs. It also inhibits CYP3A4, which may raise repaglinide levels, so the net effect on glucose is unpredictable.
How serious is the interaction between Danazol and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when danazol is started or stopped. Adjust antidiabetic doses as needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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