Drug interactions
Danazol + Pazopanib
Severity: Moderate
Danazol and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and may raise pazopanib concentrations. Increased exposure may worsen hepatotoxicity, hypertension and QT effects.
What this interaction means in plain words
Danazol and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated pazopanib metabolism by danazol.
What to do
Monitor liver function and blood pressure closely. Reduce pazopanib dose if adverse effects occur, or use an alternative to danazol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Danazol with Pazopanib?
MediHelp rates the interaction as moderate. Danazol and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a CYP3A4 inhibitor and may raise pazopanib concentrations. Increased exposure may worsen hepatotoxicity, hypertension and QT effects.
How serious is the interaction between Danazol and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function and blood pressure closely. Reduce pazopanib dose if adverse effects occur, or use an alternative to danazol.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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