Drug interactions
Danazol + Praziquantel
Severity: Minor
Danazol and Praziquantel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and may slightly raise praziquantel concentrations. Praziquantel is usually given as short courses, and clinically significant effects are not well documented.
What this interaction means in plain words
Danazol and Praziquantel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Danazol weakly inhibits CYP3A4 mediated metabolism of praziquantel.
What to do
No dose adjustment is generally needed. Be aware of increased dizziness, headache or gastrointestinal upset during the treatment course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Frequently asked questions
Can I take Danazol with Praziquantel?
MediHelp rates the interaction as minor. Danazol and Praziquantel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and may slightly raise praziquantel concentrations. Praziquantel is usually given as short courses, and clinically significant effects are not well documented.
How serious is the interaction between Danazol and Praziquantel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Be aware of increased dizziness, headache or gastrointestinal upset during the treatment course.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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