Drug interactions
Danazol + Quinine
Severity: Moderate
Danazol and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and may raise quinine concentrations. This could increase cinchonism and QT risk.
What this interaction means in plain words
Danazol and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by danazol decreasing quinine metabolism.
What to do
Monitor for tinnitus, nausea and palpitations, and consider an ECG in at-risk patients. Lower the quinine dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Danazol with Quinine?
MediHelp rates the interaction as moderate. Danazol and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a CYP3A4 inhibitor and may raise quinine concentrations. This could increase cinchonism and QT risk.
How serious is the interaction between Danazol and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tinnitus, nausea and palpitations, and consider an ECG in at-risk patients. Lower the quinine dose if toxicity develops.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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