Drug interactions
Danazol + Salmeterol
Severity: Minor
Danazol and Salmeterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak-to-moderate CYP3A4 inhibitor and may raise salmeterol exposure. This could increase beta-agonist adverse effects such as tremor, palpitations and hypokalemia, though the effect is usually modest.
What this interaction means in plain words
Danazol and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated salmeterol metabolism.
What to do
Watch for tremor, tachycardia and palpitations. Reduce use or choose an alternative if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Danazol with Salmeterol?
MediHelp rates the interaction as minor. Danazol and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak-to-moderate CYP3A4 inhibitor and may raise salmeterol exposure. This could increase beta-agonist adverse effects such as tremor, palpitations and hypokalemia, though the effect is usually modest.
How serious is the interaction between Danazol and Salmeterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for tremor, tachycardia and palpitations. Reduce use or choose an alternative if adverse effects occur.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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