Drug interactions
Danazol + Siponimod
Severity: Moderate
Danazol and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor and may increase siponimod exposure. The effect matters more in patients with reduced CYP2C9 activity, where CYP3A4 carries a larger share of siponimod clearance.
What this interaction means in plain words
Danazol and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated siponimod metabolism.
What to do
Avoid combination in patients who also take a CYP2C9 inhibitor or carry a reduced-function CYP2C9 genotype. Otherwise monitor heart rate and lymphocyte counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Danazol with Siponimod?
MediHelp rates the interaction as moderate. Danazol and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak to moderate CYP3A4 inhibitor and may increase siponimod exposure. The effect matters more in patients with reduced CYP2C9 activity, where CYP3A4 carries a larger share of siponimod clearance.
How serious is the interaction between Danazol and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination in patients who also take a CYP2C9 inhibitor or carry a reduced-function CYP2C9 genotype. Otherwise monitor heart rate and lymphocyte counts.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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