Drug interactions
Danazol + Tamoxifen
Severity: Minor
Danazol and Tamoxifen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and also has androgenic effects that oppose estrogen-related therapy. Its impact on tamoxifen is uncertain and clinical significance is unclear.
What this interaction means in plain words
Danazol and Tamoxifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition may alter tamoxifen metabolism; the effect is not well characterized.
What to do
No routine adjustment is needed. Monitor treatment response and reassess whether danazol is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Frequently asked questions
Can I take Danazol with Tamoxifen?
MediHelp rates the interaction as minor. Danazol and Tamoxifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and also has androgenic effects that oppose estrogen-related therapy. Its impact on tamoxifen is uncertain and clinical significance is unclear.
How serious is the interaction between Danazol and Tamoxifen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor treatment response and reassess whether danazol is needed.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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