Drug interactions
Danazol + Tolterodine
Severity: Minor
Danazol and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and may raise tolterodine levels. Because CYP2D6 is the main pathway in most patients, the effect is usually small but may matter in CYP2D6 poor metabolizers.
What this interaction means in plain words
Danazol and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated tolterodine metabolism by danazol.
What to do
Watch for anticholinergic adverse effects and reduce the tolterodine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Danazol with Tolterodine?
MediHelp rates the interaction as minor. Danazol and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a CYP3A4 inhibitor and may raise tolterodine levels. Because CYP2D6 is the main pathway in most patients, the effect is usually small but may matter in CYP2D6 poor metabolizers.
How serious is the interaction between Danazol and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for anticholinergic adverse effects and reduce the tolterodine dose if they occur.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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