Drug interactions
Danazol + Tolvaptan
Severity: Moderate
Danazol and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor and may raise tolvaptan levels. Increased exposure can cause excessive aquaresis, thirst and rapid sodium shifts.
What this interaction means in plain words
Danazol and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4, reducing tolvaptan clearance.
What to do
Monitor serum sodium and volume status and reduce the tolvaptan dose if excessive effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Danazol with Tolvaptan?
MediHelp rates the interaction as moderate. Danazol and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak to moderate CYP3A4 inhibitor and may raise tolvaptan levels. Increased exposure can cause excessive aquaresis, thirst and rapid sodium shifts.
How serious is the interaction between Danazol and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and volume status and reduce the tolvaptan dose if excessive effects occur.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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