Drug interactions
Danazol + Vinorelbine
Severity: Moderate
Danazol and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and may raise vinorelbine levels. This could increase hematologic and neurologic toxicity.
What this interaction means in plain words
Danazol and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4-mediated metabolism of vinorelbine.
What to do
Monitor blood counts and neuropathy and reduce the vinorelbine dose if toxicity appears. Consider alternatives to danazol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Frequently asked questions
Can I take Danazol with Vinorelbine?
MediHelp rates the interaction as moderate. Danazol and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a CYP3A4 inhibitor and may raise vinorelbine levels. This could increase hematologic and neurologic toxicity.
How serious is the interaction between Danazol and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy and reduce the vinorelbine dose if toxicity appears. Consider alternatives to danazol.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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