Drug interactions
Danshen + Flurbiprofen
Severity: Moderate
Danshen and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danshen has antiplatelet and anticoagulant activity reported and may add to the bleeding tendency of flurbiprofen. Danshen is also reported to potentiate warfarin, so concurrent use raises bleeding concern.
What this interaction means in plain words
Danshen and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects: NSAID inhibition of platelet COX-1 with herbal antiplatelet activity.
What to do
Avoid combining where possible, or counsel the patient on bleeding signs and monitor for bruising or GI bleeding, especially if also on anticoagulants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Danshen with Flurbiprofen?
MediHelp rates the interaction as moderate. Danshen and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danshen has antiplatelet and anticoagulant activity reported and may add to the bleeding tendency of flurbiprofen. Danshen is also reported to potentiate warfarin, so concurrent use raises bleeding concern.
How serious is the interaction between Danshen and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or counsel the patient on bleeding signs and monitor for bruising or GI bleeding, especially if also on anticoagulants.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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