Drug interactions
Danshen + Ibuprofen
Severity: Moderate
Danshen and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danshen (Salvia miltiorrhiza) has antiplatelet and anticoagulant effects and has been reported to potentiate warfarin. With ibuprofen, which impairs platelet function and injures gastric mucosa, bleeding risk may increase.
What this interaction means in plain words
Danshen and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects, with danshen inhibiting platelet aggregation and ibuprofen inhibiting COX-1.
What to do
Avoid combining where possible, and counsel patients to report bruising, black stools or other bleeding. Monitor closely if both are used with other antithrombotic drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Danshen with Ibuprofen?
MediHelp rates the interaction as moderate. Danshen and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danshen (Salvia miltiorrhiza) has antiplatelet and anticoagulant effects and has been reported to potentiate warfarin. With ibuprofen, which impairs platelet function and injures gastric mucosa, bleeding risk may increase.
How serious is the interaction between Danshen and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, and counsel patients to report bruising, black stools or other bleeding. Monitor closely if both are used with other antithrombotic drugs.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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