Drug interactions
Danshen + Tolmetin
Severity: Moderate
Danshen and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danshen has antiplatelet and anticoagulant-like activity and has been associated with bleeding, particularly with warfarin. With tolmetin the bleeding risk may be additive.
What this interaction means in plain words
Danshen and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effect from danshen constituents and NSAID COX inhibition.
What to do
Advise against combining where possible; if combined, monitor for bleeding and bruising.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Danshen with Tolmetin?
MediHelp rates the interaction as moderate. Danshen and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danshen has antiplatelet and anticoagulant-like activity and has been associated with bleeding, particularly with warfarin. With tolmetin the bleeding risk may be additive.
How serious is the interaction between Danshen and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against combining where possible; if combined, monitor for bleeding and bruising.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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