Drug interactions
Dapagliflozin-metformin + Ethiodized oil
Severity: Major
Dapagliflozin-metformin and Ethiodized oil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast can cause acute kidney injury, and metformin accumulation in that setting raises the risk of lactic acidosis. Ethiodized oil is given intralymphatically or intra-arterially, and systemic exposure can occur, so the risk applies mainly in renal impairment.
What this interaction means in plain words
Dapagliflozin-metformin and Ethiodized oil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Contrast-induced decline in renal function reduces metformin elimination, leading to accumulation and lactic acidosis.
What to do
Hold metformin around the procedure in patients with eGFR below 30, acute kidney injury, or intra-arterial administration. Re-check renal function about 48 hours later before resuming metformin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dapagliflozin-metformin and Ethiodized oil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Ethiodized oil?
MediHelp rates the interaction as major. Dapagliflozin-metformin and Ethiodized oil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iodinated contrast can cause acute kidney injury, and metformin accumulation in that setting raises the risk of lactic acidosis. Ethiodized oil is given intralymphatically or intra-arterially, and systemic exposure can occur, so the risk applies mainly in renal impairment.
How serious is the interaction between Dapagliflozin-metformin and Ethiodized oil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin around the procedure in patients with eGFR below 30, acute kidney injury, or intra-arterial administration. Re-check renal function about 48 hours later before resuming metformin.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
