Drug interactions
Daprodustat + Glimepiride-pioglitazone
Severity: Minor
Daprodustat and Glimepiride-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daprodustat is cleared mainly by CYP2C8, and pioglitazone is a weak CYP2C8 inhibitor. Daprodustat exposure may rise modestly, with greater erythropoietic effect and a higher risk of excessive hemoglobin increases.
What this interaction means in plain words
Daprodustat and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Daprodustat belongs to Endocrine; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Pioglitazone may weakly inhibit CYP2C8-mediated metabolism of daprodustat.
What to do
Monitor hemoglobin and adjust the daprodustat dose as needed when pioglitazone is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Daprodustat
- Daprodustat + Gemfibrozil Contraindicated
- Abiraterone + Daprodustat Moderate
- Alogliptin-pioglitazone + Daprodustat Moderate
- Carbamazepine + Daprodustat Moderate
- Clopidogrel + Daprodustat Moderate
- Daprodustat + Deferasirox Moderate
Frequently asked questions
Can I take Daprodustat with Glimepiride-pioglitazone?
MediHelp rates the interaction as minor. Daprodustat and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Daprodustat is cleared mainly by CYP2C8, and pioglitazone is a weak CYP2C8 inhibitor. Daprodustat exposure may rise modestly, with greater erythropoietic effect and a higher risk of excessive hemoglobin increases.
How serious is the interaction between Daprodustat and Glimepiride-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and adjust the daprodustat dose as needed when pioglitazone is started or stopped.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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