Drug interactions
Carbamazepine + Daprodustat
Severity: Moderate
Carbamazepine and Daprodustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may reduce daprodustat exposure and lead to loss of anemia response.
What this interaction means in plain words
Carbamazepine and Daprodustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Daprodustat belongs to Endocrine.
Why it happens
Carbamazepine induces CYP2C8, increasing daprodustat metabolism.
What to do
Monitor hemoglobin and adjust the daprodustat dose when starting or stopping carbamazepine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Daprodustat
- Daprodustat + Gemfibrozil Contraindicated
- Abiraterone + Daprodustat Moderate
- Alogliptin-pioglitazone + Daprodustat Moderate
- Clopidogrel + Daprodustat Moderate
- Daprodustat + Deferasirox Moderate
- Daprodustat + Hydrochlorothiazide-irbesartan Moderate
Frequently asked questions
Can I take Carbamazepine with Daprodustat?
MediHelp rates the interaction as moderate. Carbamazepine and Daprodustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may reduce daprodustat exposure and lead to loss of anemia response.
How serious is the interaction between Carbamazepine and Daprodustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and adjust the daprodustat dose when starting or stopping carbamazepine.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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