Drug interactions
Darifenacin + Imipramine
Severity: Moderate
Darifenacin and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine has strong anticholinergic activity and is metabolised by CYP2D6, which darifenacin inhibits. Combined use increases the risk of anticholinergic toxicity (urinary retention, constipation, confusion, tachycardia) and may raise tricyclic concentrations.
What this interaction means in plain words
Darifenacin and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Imipramine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects and CYP2D6 inhibition by darifenacin reducing imipramine clearance.
What to do
Monitor for anticholinergic effects and tricyclic toxicity, including ECG if the dose is high. Consider a lower imipramine dose or a non-antimuscarinic bladder agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Darifenacin with Imipramine?
MediHelp rates the interaction as moderate. Darifenacin and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine has strong anticholinergic activity and is metabolised by CYP2D6, which darifenacin inhibits. Combined use increases the risk of anticholinergic toxicity (urinary retention, constipation, confusion, tachycardia) and may raise tricyclic concentrations.
How serious is the interaction between Darifenacin and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and tricyclic toxicity, including ECG if the dose is high. Consider a lower imipramine dose or a non-antimuscarinic bladder agent.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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