Drug interactions
Darifenacin + Ivosidenib
Severity: Moderate
Darifenacin and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower darifenacin concentrations, reducing control of overactive bladder symptoms. The effect is a loss of efficacy rather than toxicity.
What this interaction means in plain words
Darifenacin and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induction of CYP3A4 increases darifenacin clearance.
What to do
Monitor for loss of symptom control and consider an alternative agent not dependent on CYP3A4 if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Darifenacin with Ivosidenib?
MediHelp rates the interaction as moderate. Darifenacin and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower darifenacin concentrations, reducing control of overactive bladder symptoms. The effect is a loss of efficacy rather than toxicity.
How serious is the interaction between Darifenacin and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control and consider an alternative agent not dependent on CYP3A4 if efficacy declines.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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