Drug interactions
Darifenacin + Lorlatinib
Severity: Minor
Darifenacin and Lorlatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4 and may lower darifenacin concentrations, potentially reducing efficacy for overactive bladder.
What this interaction means in plain words
Darifenacin and Lorlatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Lorlatinib belongs to Oncology.
Why it happens
CYP3A4 induction by lorlatinib increases darifenacin metabolism.
What to do
Monitor bladder symptom control and increase darifenacin to the higher labeled dose if needed, or consider an alternative agent.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Darifenacin with Lorlatinib?
MediHelp rates the interaction as minor. Darifenacin and Lorlatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorlatinib induces CYP3A4 and may lower darifenacin concentrations, potentially reducing efficacy for overactive bladder.
How serious is the interaction between Darifenacin and Lorlatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bladder symptom control and increase darifenacin to the higher labeled dose if needed, or consider an alternative agent.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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