Drug interactions
Darifenacin + Nifedipine
Severity: Minor
Darifenacin and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is metabolized by CYP3A4, and nifedipine is a weak CYP3A4 substrate and not a significant inhibitor. A clinically important change in darifenacin levels is unlikely, though additive constipation is possible.
What this interaction means in plain words
Darifenacin and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Nifedipine belongs to Cardiovascular.
Why it happens
Nifedipine has minimal CYP3A4 inhibitory effect, so any increase in darifenacin exposure is theoretical.
What to do
No dose adjustment is needed. Monitor for anticholinergic adverse effects such as dry mouth and constipation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Nifedipine
Frequently asked questions
Can I take Darifenacin with Nifedipine?
MediHelp rates the interaction as minor. Darifenacin and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darifenacin is metabolized by CYP3A4, and nifedipine is a weak CYP3A4 substrate and not a significant inhibitor. A clinically important change in darifenacin levels is unlikely, though additive constipation is possible.
How serious is the interaction between Darifenacin and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for anticholinergic adverse effects such as dry mouth and constipation.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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