Drug interactions
Darifenacin + Oxybutynin
Severity: Moderate
Darifenacin and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinic bladder agents, so combining them offers little added benefit while increasing dry mouth, constipation, blurred vision, urinary retention and cognitive effects.
What this interaction means in plain words
Darifenacin and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Oxybutynin belongs to Genitourinary.
Why it happens
Therapeutic duplication with additive muscarinic receptor blockade.
What to do
Avoid concurrent use of two antimuscarinic bladder agents; choose a single drug and optimize its dose. If combined, monitor for retention and anticholinergic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Oxybutynin?
MediHelp rates the interaction as moderate. Darifenacin and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinic bladder agents, so combining them offers little added benefit while increasing dry mouth, constipation, blurred vision, urinary retention and cognitive effects.
How serious is the interaction between Darifenacin and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two antimuscarinic bladder agents; choose a single drug and optimize its dose. If combined, monitor for retention and anticholinergic toxicity.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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