Drug interactions
Darifenacin + Paroxetine
Severity: Minor
Darifenacin and Paroxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine is a strong CYP2D6 inhibitor and CYP2D6 contributes to darifenacin metabolism, so darifenacin exposure can rise modestly. Both agents can also contribute anticholinergic effects such as dry mouth and constipation.
What this interaction means in plain words
Darifenacin and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Paroxetine belongs to Central Nervous System.
Why it happens
Paroxetine inhibits CYP2D6, reducing darifenacin clearance, with some additive anticholinergic effect.
What to do
No dose change is usually required; monitor for anticholinergic effects such as dry mouth, constipation and urinary retention.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Darifenacin with Paroxetine?
MediHelp rates the interaction as minor. Darifenacin and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paroxetine is a strong CYP2D6 inhibitor and CYP2D6 contributes to darifenacin metabolism, so darifenacin exposure can rise modestly. Both agents can also contribute anticholinergic effects such as dry mouth and constipation.
How serious is the interaction between Darifenacin and Paroxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; monitor for anticholinergic effects such as dry mouth, constipation and urinary retention.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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