Drug interactions
Darifenacin + Timolol
Severity: Moderate
Darifenacin and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is a moderate CYP2D6 inhibitor and timolol is partly cleared by CYP2D6, so beta-blocker exposure could increase, particularly with systemic timolol or heavy ophthalmic use. This may cause bradycardia or hypotension in susceptible patients.
What this interaction means in plain words
Darifenacin and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Timolol belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6-mediated timolol metabolism by darifenacin.
What to do
Monitor heart rate and blood pressure when oral timolol is used; for eye drops, watch for systemic beta-blocker effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Darifenacin with Timolol?
MediHelp rates the interaction as moderate. Darifenacin and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darifenacin is a moderate CYP2D6 inhibitor and timolol is partly cleared by CYP2D6, so beta-blocker exposure could increase, particularly with systemic timolol or heavy ophthalmic use. This may cause bradycardia or hypotension in susceptible patients.
How serious is the interaction between Darifenacin and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when oral timolol is used; for eye drops, watch for systemic beta-blocker effects.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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