Drug interactions
Darifenacin + Tolvaptan
Severity: Minor
Darifenacin and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is not a significant CYP3A4 inhibitor, so a meaningful rise in tolvaptan exposure is not expected.
What this interaction means in plain words
Darifenacin and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Tolvaptan belongs to Endocrine.
Why it happens
No established mechanism; darifenacin does not materially inhibit CYP3A4.
What to do
No adjustment is needed; continue standard monitoring of serum sodium during tolvaptan therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Darifenacin with Tolvaptan?
MediHelp rates the interaction as minor. Darifenacin and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darifenacin is not a significant CYP3A4 inhibitor, so a meaningful rise in tolvaptan exposure is not expected.
How serious is the interaction between Darifenacin and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; continue standard monitoring of serum sodium during tolvaptan therapy.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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