Drug interactions
Dasabuvir + Irinotecan
Severity: Major
Dasabuvir and Irinotecan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasabuvir inhibits UGT1A1, which detoxifies SN-38. Higher SN-38 exposure may cause severe diarrhea and neutropenia.
What this interaction means in plain words
Dasabuvir and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of UGT1A1 reduces SN-38 glucuronidation.
What to do
Avoid if possible; otherwise monitor closely for diarrhea and neutropenia and consider reducing irinotecan dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Frequently asked questions
Can I take Dasabuvir with Irinotecan?
MediHelp rates the interaction as major. Dasabuvir and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasabuvir inhibits UGT1A1, which detoxifies SN-38. Higher SN-38 exposure may cause severe diarrhea and neutropenia.
How serious is the interaction between Dasabuvir and Irinotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor closely for diarrhea and neutropenia and consider reducing irinotecan dose.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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