Drug interactions
Daunorubicin + Rifampin
Severity: Moderate
Daunorubicin and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces P-glycoprotein and other clearance pathways and may lower daunorubicin exposure. This could reduce antileukemic efficacy, though clinical evidence is limited.
What this interaction means in plain words
Daunorubicin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces P-gp and metabolic enzymes, increasing daunorubicin clearance.
What to do
Avoid rifampin if alternatives exist; otherwise monitor treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
- Daunorubicin + Fingolimod Major
Frequently asked questions
Can I take Daunorubicin with Rifampin?
MediHelp rates the interaction as moderate. Daunorubicin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces P-glycoprotein and other clearance pathways and may lower daunorubicin exposure. This could reduce antileukemic efficacy, though clinical evidence is limited.
How serious is the interaction between Daunorubicin and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid rifampin if alternatives exist; otherwise monitor treatment response.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporin. The full list is on the Daunorubicin page.
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