Drug interactions
Decitabine + Dengue vaccine
Severity: Major
Decitabine and Dengue vaccine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is live attenuated, and decitabine-related immunosuppression can reduce vaccine response and increase the risk of vaccine-associated infection.
What this interaction means in plain words
Decitabine and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Immunosuppression by decitabine reduces vaccine response and may permit replication of live attenuated virus.
What to do
Avoid live vaccines during treatment and defer vaccination until immune recovery. Use non-live alternatives where available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Decitabine
- Decitabine + Etrasimod Major
- Decitabine + Fingolimod Major
- Decitabine + Palifermin Major
- Decitabine + Ropeginterferon alfa 2b Major
- Decitabine + Siponimod Major
- Acalabrutinib + Decitabine Moderate
Frequently asked questions
Can I take Decitabine with Dengue vaccine?
MediHelp rates the interaction as major. Decitabine and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is live attenuated, and decitabine-related immunosuppression can reduce vaccine response and increase the risk of vaccine-associated infection.
How serious is the interaction between Decitabine and Dengue vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during treatment and defer vaccination until immune recovery. Use non-live alternatives where available.
What other medicines interact with Decitabine?
MediHelp also lists interactions of Decitabine with, for example, Etrasimod, Fingolimod, Palifermin. The full list is on the Decitabine page.
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