Drug interactions
Decitabine + Etrasimod
Severity: Major
Decitabine and Etrasimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocytes and decitabine causes myelosuppression. Together they may increase the risk of serious infection, and the combination has not been studied.
What this interaction means in plain words
Decitabine and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Decitabine belongs to Oncology; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression: S1P receptor modulation sequesters lymphocytes while decitabine suppresses bone marrow function.
What to do
Avoid concurrent use where possible and consider an alternative to etrasimod during decitabine therapy. If used together, monitor blood counts and for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Decitabine
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Decitabine with Etrasimod?
MediHelp rates the interaction as major. Decitabine and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocytes and decitabine causes myelosuppression. Together they may increase the risk of serious infection, and the combination has not been studied.
How serious is the interaction between Decitabine and Etrasimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and consider an alternative to etrasimod during decitabine therapy. If used together, monitor blood counts and for infection.
What other medicines interact with Decitabine?
MediHelp also lists interactions of Decitabine with, for example, Dengue vaccine, Fingolimod, Palifermin. The full list is on the Decitabine page.
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