Drug interactions
Deferasirox + Desogestrel-ethinyl estradiol
Severity: Moderate
Deferasirox and Desogestrel-ethinyl estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can induce CYP3A4 and may lower ethinyl estradiol exposure, possibly reducing contraceptive reliability. Labeling advises caution with hormonal contraceptives.
What this interaction means in plain words
Deferasirox and Desogestrel-ethinyl estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Desogestrel-ethinyl estradiol belongs to Endocrine.
Why it happens
Deferasirox may induce CYP3A4/UGT-mediated metabolism of ethinyl estradiol, lowering its concentrations.
What to do
Add a non-hormonal barrier method while on deferasirox; consider a non-hormonal contraceptive alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as moderate. Deferasirox and Desogestrel-ethinyl estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can induce CYP3A4 and may lower ethinyl estradiol exposure, possibly reducing contraceptive reliability. Labeling advises caution with hormonal contraceptives.
How serious is the interaction between Deferasirox and Desogestrel-ethinyl estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Add a non-hormonal barrier method while on deferasirox; consider a non-hormonal contraceptive alternative.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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