Drug interactions
Deferasirox + Efavirenz
Severity: Moderate
Deferasirox and Efavirenz: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may modestly change efavirenz concentrations, but the effect is not well characterized. Deferasirox is itself reduced by inducers such as efavirenz via UGT induction, which may lessen iron chelation.
What this interaction means in plain words
Deferasirox and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz may induce UGT-mediated deferasirox glucuronidation, lowering chelator exposure; the reverse effect on efavirenz is uncertain.
What to do
Monitor serum ferritin and consider deferasirox dose increase if iron control worsens. Monitor virologic response and efavirenz tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Efavirenz?
MediHelp rates the interaction as moderate. Deferasirox and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox may modestly change efavirenz concentrations, but the effect is not well characterized. Deferasirox is itself reduced by inducers such as efavirenz via UGT induction, which may lessen iron chelation.
How serious is the interaction between Deferasirox and Efavirenz?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum ferritin and consider deferasirox dose increase if iron control worsens. Monitor virologic response and efavirenz tolerability.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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