Drug interactions
Deferasirox + Eptifibatide
Severity: Moderate
Deferasirox and Eptifibatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can cause gastric ulceration and gastrointestinal hemorrhage. Eptifibatide strongly inhibits platelet aggregation, so bleeding from such lesions may be more severe.
What this interaction means in plain words
Deferasirox and Eptifibatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Eptifibatide belongs to Cardiovascular.
Why it happens
Deferasirox-related GI mucosal injury combined with eptifibatide's antiplatelet effect increases hemorrhage risk.
What to do
Monitor for GI bleeding signs and hemoglobin during co-administration. Consider a proton pump inhibitor in patients at higher GI risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eptifibatide
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Eptifibatide?
MediHelp rates the interaction as moderate. Deferasirox and Eptifibatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can cause gastric ulceration and gastrointestinal hemorrhage. Eptifibatide strongly inhibits platelet aggregation, so bleeding from such lesions may be more severe.
How serious is the interaction between Deferasirox and Eptifibatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding signs and hemoglobin during co-administration. Consider a proton pump inhibitor in patients at higher GI risk.
What other medicines interact with Eptifibatide?
MediHelp also lists interactions of Eptifibatide with, for example, Abrocitinib, Acalabrutinib, Acetylsalicylic acid. The full list is on the Eptifibatide page.
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